Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity connected to bortezomib, a proteasome inhibitor Employed in the cure of various myeloma. Its synthesis or analyze is very important for making sure the purity and safety from the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor in the synthesis of abiraterone acetate, a drug used in the cure of prostate cancer by inhibiting androgen creation.
Imatinib Intermediate (CAS NO. 152460-ten-one): A important compound inside the synthesis of imatinib, a drug that targets precise varieties of cancer, which includes chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound used in the synthesis of docetaxel, a chemotherapy medication that treats different cancers like breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): They are intermediates during the synthesis of gemcitabine, an anti-most cancers drug. Their examine is very important for optimizing the manufacturing course of action and making certain superior purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is made use of to deal with breast most cancers, and these intermediates are involved with its production.
Fulvestrant Intermediates: Fulvestrant is undoubtedly an estrogen receptor antagonist Employed in the therapy of breast most cancers. Many intermediates help in the synthesis of this drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-16-nine): This intermediate is Utilized 5'-dibenzoate in the synthesis of paclitaxel, a chemotherapy drug successful in dealing with cancers for example ovarian, breast, and lung most cancers.
three. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Utilized in the treatment of colorectal cancer and smaller mobile lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is involved with the synthesis of adamantane derivatives, which have several applications, like antiviral Houses.
Vildagliptin Intermediates: Utilized in the manufacture of vildagliptin, an oral drug for form two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar stages.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-1): This compound is involved in the synthesis of various gluconic acid derivatives, which can be used in meals, pharmaceutical, and industrial CAS NO. 848133-35-7 programs.
Canagliflozin Intermediate 2: A precursor within the synthesis of canagliflozin, a medication applied to handle variety two diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).